Publications
Selected publications showcasing work from our research focus areas are shown below. For a full list of publications by the Singanayagam Group please visit - Aran Singanayagam
Neutrophil extracellular traps promote immunopathogenesis of virus-induced COPD exacerbations
Orestis Katsoulis, Marie Toussaint, Millie M. Jackson, Patrick Mallia, Joseph Footitt, Kyle T. Mincham, Garance F. M. Meyer, Tata Kebadze, Amy Gilmour, Merete Long, Andrew D. Aswani, Robert J. Snelgrove, Sebastian L. Johnston, James D. Chalmers, Aran Singanayagam
Obesity dysregulates the pulmonary antiviral immune response
Mark Almond, Hugo A. Farne, Millie M. Jackson, Akhilesh Jha, Orestis Katsoulis, Oliver Pitts, Tanushree Tunstall, Eteri Regis, Jake Dunning, Adam J. Byrne, Patrick Mallia, Onn Min Kon, Ken A. Saunders, Karen D. Simpson, Robert J. Snelgrove, Peter J. M. Openshaw, Michael R. Edwards, Wendy S. Barclay, Liam M. Heaney, Sebastian L. Johnston, Aran Singanayagam
A persistent neutrophil-associated immune signature characterizes post–COVID-19 pulmonary sequelae
Peter M George, Anna Reed, Sujal R Desai, Anand Devaraj, Tasnim Shahridan Faiez, Sarah Laverty, Amama Kanwal, Camille Esneau , Michael K C Liu , Faisal Kamal , William D-C Man, Sundeep Kaul, Suveer Singh, Georgia Lamb, Fatima K Faizi , Michael Schuliga, Jane Read, Thomas Burgoyne, Andreia L Pinto, Jake Micallef, Emilie Bauwens, Julie Candiracci, Mhammed Bougoussa, Marielle Herzog, Lavanya Raman, Blerina Ahmetaj-Shala, Stuart Turville, Anupriya Aggarwal, Hugo A Farne, Alessia Dalla Pria, Andrew D Aswani, Francesca Patella, Weronika E Borek, Jane A Mitchell, Nathan W Bartlett, Arran Dokal, Xiao-Ning Xu, Peter Kelleher, Anand Shah, Aran Singanayagam
Airway-delivered short-chain fatty acid acetate boosts antiviral immunity during rhinovirus infection
Krist Helen Antunes, Aran Singanayagam, Lily Williams , Tasnim Syakirah Faiez, Ana Farias, Millie M Jackson, Fatima K Faizi, Julia Aniscenko, Tatiana Kebadze, Punnam Chander Veerati, Lisa Wood, Nathan W Bartlett, Ana Paula Duarte de Souza, Sebastian L Johnston
Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease
Aran Singanayagam, Joseph Footitt, Matthias Marczynski, Giorgia Radicioni, Michael T. Cross, Lydia J. Finney, Maria-Belen Trujillo-Torralbo, Maria Calderazzo, Jie Zhu, Julia Aniscenko, Thomas B. Clarke, Philip L. Molyneaux, Nathan W. Bartlett, Miriam F. Moffatt, William O. Cookson, Jadwiga Wedzicha, Christopher M. Evans, Richard C. Boucher, Mehmet Kesimer, Oliver Lieleg, Patrick Mallia, and Sebastian L. Johnston
Virus-induced Volatile Organic Compounds Are Detectable in Exhaled Breath during Pulmonary Infection
Faisal Kamal*, Sacheen Kumar*, Michael R. Edwards, Kirill Veselkov, Ilaria Belluomo, Tatiana Kebadze, Andrea Romano, Maria-Belen Trujillo-Torralbo, Tasnim Shahridan Faiez, Ross Walton, Andrew I. Ritchie, Dexter J. Wiseman, Ivan Laponogov, Gavin Donaldson, Jadwiga A. Wedzicha, Sebastian L. Johnston, Aran Singanayagam*, and George B. Hanna*
Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon
Journal of Clinical Allergy and Immunology (2021)
DOI: 10.1016/j.jaci.2020.09.034
Lydia J Finney, Nicholas Glanville, Hugo Farne, Julia Aniscenko, Peter Fenwick, Samuel V Kemp, Maria-Belen Trujillo-Torralbo, Su Ling Loo, Maria Adelaide Calderazzo, Jadwiga A Wedzicha, Patrick Mallia, Nathan W Bartlett, Sebastian L Johnston, Aran Singanayagam
Inhaled corticosteroid suppression of cathelicidin drives dysbiosis and bacterial infection in chronic obstructive pulmonary disease
Aran Singanayagam, Nicholas Glanville, Leah Cuthbertson, Nathan W Bartlett, Lydia J Finney, Elena Turek, Eteri Bakhsoliani, Maria Adelaide Calderazzo, Maria-Belen Trujillo-Torralbo, Joseph Footitt, Phillip L James, Peter Fenwick, Samuel V Kemp, Thomas B Clarke, Jadwiga A Wedzicha, Michael R Edwards, Miriam Moffatt, William O Cookson, Patrick Mallia, Sebastian L Johnston
Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations
DOI: 10.1038/s41467-018-04574-1
Aran Singanayagam, Nicholas Glanville, Jason L. Girkin, Yee Man Ching, Andrea Marcellini, James D. Porter, Marie Toussaint, Ross P. Walton, Lydia J. Finney, Julia Aniscenko, Jie Zhu, Maria-Belen Trujillo-Torralbo, Maria Adelaide Calderazzo, Chris Grainge, Su-Ling Loo, Punnam Chander Veerati, Prabuddha S. Pathinayake, Kristy S. Nichol, Andrew T. Reid, Phillip L. James, Roberto Solari, Peter A. B. Wark, Darryl A. Knight, Miriam F. Moffatt, William O. Cookson, Michael R. Edwards, Patrick Mallia, Nathan W. Bartlett & Sebastian L. Johnston