Bronchiectasis is a chronic lung condition characterised by susceptibility to exacerbations, which are a major contributor its morbidity and mortality. It was previously held that bacteria cause most of these exacerbations, however emerging evidence indicates that viruses could be a trigger in up to half. We are adopting multi-omic profiling within in vitro models and unique human viral challenge studies to define the mechanisms that drive exacerbation susceptibility in bronchiectasis. We hope to drive future development of effective preventative and therapeutic strategies.