The Singanayagam lab uses cutting edge immunological and molecular microbiological techniques to elucidate the functional roles of commensal bacteria, viruses and fungi residing in the respiratory tract. Working at the interface of basic and clinical research, we focus on how commensals within the microbiota regulate immune homeostasis in health and how perturbations that occur in chronic lung diseases such as COPD, asthma and bronchiectasis lead to immune dysregulation and impaired protection against pathogens.​