The Singanayagam lab uses cutting edge immunological and molecular microbiological techniques to elucidate the functional roles of commensal bacteria, viruses and fungi residing in the respiratory tract. Working at the interface of basic and clinical research, we focus on how commensals within the microbiota regulate immune homeostasis in health and how perturbations that occur in chronic lung diseases such as COPD, asthma and bronchiectasis lead to immune dysregulation and impaired protection against pathogens.
'A persistent neutrophil-associated immune signature characterizes post-COVID-19 pulmonary sequelae'
A substantial number of individuals who recover from Covid-19 present with long-term sequelae (consequences of a previous disease or injury). By following patients who had recently recovered from severe Covid-19, a neutrophil-associated inflammatory phenotype was found in those with persistent pulmonary symptoms, while neutrophil extracellular traps (NETS) were found in the blood. These data point to a potential role for neutrophils in pulmonary long COVID …