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Research Overview

The Singanayagam lab uses cutting edge immunological and molecular microbiological techniques to elucidate the functional roles of commensal bacteria, viruses and fungi residing in the respiratory tract. Working at the interface of basic and clinical research, we focus on how commensals within the microbiota regulate immune homeostasis in health and how perturbations that occur in chronic lung diseases such as COPD, asthma and bronchiectasis lead to immune dysregulation and impaired protection against pathogens.​

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Latest Publications

Neutrophil extracellular traps promote immunopathogenesis of virus-induced COPD exacerbations

Respiratory viruses are a major trigger of exacerbations in chronic obstructive pulmonary disease (COPD). Airway neutrophilia is a hallmark feature of stable and exacerbated COPD but roles played by neutrophil extracellular traps (NETS) in driving disease pathogenesis are unclear. Here, using human studies of experimentally-induced and naturally-occurring exacerbations we identify that rhinovirus infection induces airway NET formation which is amplified in COPD and correlates with magnitude of inflammation and clinical exacerbation severity...

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